29+ Genetic Mutations That Resulted in Beautifully Unique Features

Layla Harris

weird /
Instagram via @officialmekhilucky_

While some have shaped birthmarks and freckles, others have unique genetic skin conditions that we are still learning about today. Let's take a look at the many mutations that resulted in gorgeous humans.

Partial Heterochromia 

This beautiful brown and grey eye is from a person that the American Academy of Ophthalmology (AAO) would suggest has Partial Heterochromia. This remarkable condition doesn't occur often, but wow, so captivating!

Partial Heterochromia Unique Traits
Reddit via u/Nico_LaBras

The AAO explained that this occurs when a person's iris has variations in the distribution of melanin or pigment, giving color to our eyes and skin. The beautiful trait must be an eye-catching conversation starter at any party or event this person attends!


The owner of this hand, Twitter user @vF_KROADER, has referred to it as his "Good hand," joking that it gives him increased ability with a video game controller. While it might seem out of the ordinary for those of us with 5 fingers on each hand, this gamer was born just as depicted in the photo below.

Symbrachydactyly Hands Human Trait
Twitter via @vF_KROADER

The Boston Children's Hospital reported that this condition could be referred to as Symbrachydactyly, a rare congenital trait. It can be displayed by a hand with fingers that were not formed normally, whether that may be extra long or short, webbed, or conjoined.

Preauricular Pits 

Possibly surprising to some, this interesting hole in the ear is not simply a piercing missing an earring. Instead, Healthline would suggest this person could have been born with Preauricular Pits, a condition resulting in a small hole in the front of one's ear.

Preauricular Pits Ear Trait
YouTube via Business Insider

This little hole interestingly connects to a sinus tract under the person's skin. While it's reportedly not painful, it does look like a great place to put the newest accessory added to the jewelry box. But, we've looked it up, and the professionals advise against it.

Waardenburg Syndrome

Believe it or not, this gorgeous eye doesn't have white mascara on; they were simply born with 2-tone eyelashes! The National Organization for Rare Disorders (NORD) explained that this striking trait could occur on a person's eyebrows, eyelashes, or scalp.

Waardenburg Syndrome Eyelashes NORD
Reddit via u/HeroOfTime4209

The color of this person's eye is undoubtedly amplified by the cluster of eyelashes that have prematurely turned lighter. Interestingly, NORD reported that this beautiful occurrence could happen anywhere from mid-childhood to early adulthood in those who have the genetic trait for it.

Café-Au-Lait Spots 

Some best friends buy matching bracelets or shirts, but this pair has nearly identical yet opposite birthmarks! The C.S. Mott Children's Hospital has suggested the official name of this kind of formation as Café-au-lait Spots. They are said to be smooth marks visible since birth.

Café-Au-Lait Spots
Reddit via u/camicat42

We can guess that means these besties were destined to cross paths since the day they were born! An article produced by the hospital described the birthmarks as a contained overgrowth of cells, typically oval in shape, ranging from light to dark brown in color.


The AAO determined 1 out of every 5 people have differing pupil sizes, many of which do not experience issues. But, for those who may have preexisting nervous system conditions, a history of eye damage, or viral infections, their eye might look something like this girl's.

anisocoria, genetic mutations, unique
Instagram via @prosperity_woman

While it might look different than a typical set of eyes, this unique trait has not been reported to affect eye health or vision negatively. Time to take a look in the mirror, people! Some of us might just be the lucky ones with the cool conversation starter.

Generational Waardenburg Syndrome 

This adorable little girl's hair color is remarkable enough, but she actually matches with her mother as well! This, however, is not a case of a trip to the hairdresser. Instead, according to MedlinePlus, it is thought to be thanks to an autosomal dominant set of genes.

Genetic mutations, waardenburg, feature
Facebook via Brianna Worthy

The National Organization for Rare Disorders has referred to this kind of generational trait as Waardenburg Syndrome. According to the group, this family might carry genes that are subject to highly diminished pigmentation of their hair. What a beautiful trait to bond these two!

Dystopia Canthorum

NORD explained that this type of Waardenburg Syndrome, WS1, which includes the unique "Sideways displacement of the inner angles of the eyes," is referred to as Dystopia Canthorum. While his snowy-white head of luscious locks is what may have caught the eye first, his charming eyes have stolen our heart.

Genetic mutation, waardenburg, eyes
Reddit via u/Cohacq

In an interesting twist of events, NORD reported that there might be no apparent family history of the condition in people who have these unique features. In these cases, researchers suggest that it may sometimes come from a new genetic mutation developing for unknown reasons.  


Most of us remember seeing this skin condition when music icon Michael Jackson used to grace stages worldwide. This individual here is in the same approximate 1% of the world’s population whose bodies do not produce melanin to their skin, otherwise known as Vitiligo.  

Human Skin Trait Vitiligo
Whatpadd via @cocoapebbles

Healthline defined Vitiligo as when a person's cells that are responsible for the skin's color are destroyed. Once these cells lose the ability to produce melanin, those areas of the skin turn visibly white, no matter what a person's complexion looks like.  

Triphalangeal Thumb 

At a glance, these might look like any other hands, but a double-take shows that this person's thumbs are not thumbs at all! Instead, they are 5th fingers that replicate the other 4. MedlinePlus suggested that this unique feature can come from having an extra bone or joint in the thumb, causing it to look like an ordinary finger.

Unique Hands Triphalangeal Thumb
Reddit via u/NoThanks93330

MedlinePlus further hypothesized that this unique condition could be referred to as Triphalangeal Thumb. It's said to be a type of DOORS Syndrome, where the finger's abnormalities are present from birth. Thus, many people with hands like these have become used to it over time. 

Oculocutaneous Albinism 

Believe it or not, every member of this cheery-looking Indian family carries the same genes of albinism. According to MedlinePlus, this form of genetic difference is called Oculocutaneous Albinism and is characterized by affected pigmentation of the hair, skin, and eyes. 

Oculocutaneous Albinism Generational Trait
Reddit via u/ArkadiusBear

These individuals are said to portray lighter-colored features and even have reduced pigmentation in the irises of their eyes. In addition, the medical group said that this form of albinism is most oftentimes inherited via an autosomal recessive pattern. Meaning, this has been part of this family's history for many generations.

Single Palmar Crease 

If boredom has ever taken one as far as to study the lines on their hands, one might have realized that they have about 3 curved lines on the inside of their palm. However, if a solid straight-line dominates the palm, MedlinePlus refers to that as a Single Palmar Crease or Simian Crease.

Single Palmar Crease Unique
Facebook via Chirologie Luxembourg

It is hypothesized statistically speaking that approximately 1 out of 30 people have this condition, as MedlinePlus reports. But, if you're searching and cannot find it, don't fret! Men are supposedly twice as likely as females to own this intriguing feature.


Many in the medical community have described Arachnodactyly, AKA Spider Fingers, as when a person has abnormally long and slender fingers. The National Organization for Rare Disorders explained that permanently flexed extremities could also characterize this unique human trait.

Unique Human Feet Arachnodactyly
Twitter via @JordanRasko

According to NORD, this interesting condition could include the long-lasting fixation of joints such as the fingers, toes, knees, elbows, and hips. While most can't imagine what this might be like, others are in our boat of thinking about the many toe rings this person could accessorize with.


Even in the summers, those with Raynaud's - or what NORD described as a vascular disorder, or poor circulation and blood flow to the limbs - is more common than people think. The organization stated, although it's caused by "Episodes of constriction of very small blood vessels" in the fingers and toes, it's essentially painless.

Raynaud’s Human Genetic Trait
Reddit via u/love_me_some_dave

While this poor circulation is characterized by a person's normal skin tone turning paper-white, it's typically deemed an autoimmune disease due to the poor circulation. Thus, a non-profit organization called The Raynaud's Association was formed to help those who have the trait cope and participate in daily activities.

Hypermobile Joints 

Healthline deemed these interesting-looking knuckles as hypermobile joints. They, according to the health industry, are often chalked up to double jointedness. However, these genetically pushed-back knuckles are very uncommon and are said actually to be caused by loose ligaments in the body. 

Hypermobile Joints Unique Humans
Reddit via u/OstrichBakedGhoul

According to Healthline, this interesting ability can be characterized by a person having the ability to extend their body parts easily. Whether it be individual fingers, knuckles, shoulder blades, etc., people with Hypermobile Joints have the ability to move past the normal range of motion. 

Connie’s Birthmark 

Adorable Connie Lloyd (left) was born with a bright red birthmark on her nose. However, doctors did warn Connie's parents that if her birthmark were to be disturbed, great danger could come her way. Thus, the Lloyd family had to make a life-changing decision.

Connie, Birthmark, Mutation, Bizarre
Facebook via Zara Louise Green

After Doctors warned the Lloyd family about the severe risks of even a mere scratch on Connie's bright red birthmark, the family decided to op-in to surgery to get their little girl's nose fixed from all traces of the mark. Thankfully, the surgery was successful, and Connie lives with nearly all traces removed!

Port-Wine Stain 

Healthline described this person's Port-Wine Stain, or Nevus Flammeus, as a type of birthmark. However, this unique trait can take many different forms depending on the human with which it is formed. It's been reported that the size of each stain can range from a mere millimeter to several centimeters. 

Port wine stain, Mutation
Instagram via @lenka_gotart

Although the stains can appear anywhere on the body, Healthline suggested that the more common areas are: "One side of the face, head, and neck, but they may also affect the abdomen, legs, or arms." In this example, the woman in the photo has hers spread across her face.

Heterochromia Iridium 

There's simply no denying that Hollywood's Kate Bosworth has a stunning set of eyes. In fact, her unique windows to the soul happen to be different colors! Referred to as Heterochromia Iridium by Healthline, Bosworth has one blue eye, the other half brown, half blue.

Heterochromia Iridium Kate Bosworth
Instagram via @katebosworth

NORD suggested that the formation of this unique trait can be due to the underdevelopment of the connective tissue within the eye. While this might sound scary, Kate has assured that the intriguing coloring of her eyes is painless to her. And, knowing that, we enjoy them even more!


According to the National Organization for Albinism and Hypopigmentation (NOAH), about 1 in 19,000 people in the United States have a form of albinism. Thus, people like this snow angel-looking model have a complete absence of melanin. As for what that means?

Albino, Genetic mutation, Unique
Instagram via @sollarsamuel

It has been widely reported that individuals and families alike that have OCA1a have an undeniably unique look to them. From white hair to extremely fair skin, many of their light eyes sparkle in the sun or the outdoors. Talk about eye-catching beauty!


For years, it has been said that every freckle represents the kiss of an angel. And, while many of us have believed it to be true, it turns out that freckles are actually the result of good old genetics and sunshine. In fact, Healthline dove into a deeper explanation.

Freckles Human Trait Genes
Helmut Meyer Zur Capellen/imageBROKER/Shutterstock via Shutterstock

Of the 2 kinds of freckles, there are Ephelides and Solar Lentigines. The former is the more common picture that comes to mind when people think about freckles. The latter is made up of dark patches of skin, more prominent freckles that develop during adulthood.

Absent Wisdom Teeth

According to the Dental Research JournalTrusted Source, it's believed that an estimated 5 to 37% of people are missing one or more of their third molars, known as Wisdom Teeth. And, while the reason is still unknown, the organization hypothesized it being due to individual genetics. 

Abnormal Absent Wisdom Teeth
Reddit via u/zigzagman1031

While there are many who have to go through the painful surgery and long recovery time of getting one's Wisdom Teeth removed, Healthline reported some interesting data. According to them, approximately 20% of people are born without this set of teeth. And the rest? Well, they take a less-favored trip to the orthodontist. 

Morton’s Toe

Believe it or not, these feet belong to the one and only Meghan Markle! And, while taking a closer look, one may notice that her second toes are significantly longer than her big toes. This is what Healthline refers to as Morton's Toe or Morton's Foot. 

Meghan Markle Morton’s Toe
Michael Tullberg / Contributor via Getty Images

While this longer growth of the second metatarsal is painless to the toe for most, it's been reported to increase the chances of developing calluses or pain on the soles of one's feet. And, a little known fact, Markle isn't the only one with Morton's Toe; the Statue of Liberty is rumored to have it as well!

“Outie” Navels 

This might come as a shock to many, but the direction of one's belly button has nothing to do with how an umbilical cord was cut or clamped at birth. In fact, Healthline reported that having an "outie" Navel is quite normal and harmless, not to mention unique!

Outie Navels Unique Bellybutton
Instagram via @annaolivia.jonsson

Even though they are seen less often than navels that turn inward, these kinds of outwards-facing belly buttons are reportedly harmless. However, there is a rare chance that those with this trait might be in danger of their intestines becoming trapped. This is highly unlikely but possible.

Orange Hair

Red, orange, or ginger-colored hair is widely thought of as a unique trait in both men and women. Having this bright color so close to other facial features often makes one's eye color pop brighter. On top of that, these lucky people are among the world's small but mighty population of 1-2% to rock the red locks.

Emma stone, red hair
Caroline McCredie/Getty Images

Healthline hypothesized that these individuals with fire-colored hair are the holders of a special genetic mutation that resulted in their hair being the color it is. From all ranges of red to orange, people with this extravagant hair color are often envied by many. 

“X” Palm Line

The National Organization for Rare Disorders hypothesized that at least 3% of the world's population has this interesting "X" shape on their palms. As mentioned before, humans typically have 3 lines that curve across the inside of their hands. However, this is yet another abnormality.

X Palm Line Unique
YouTube via Pebbles Live

Here, instead of smooth curved lines, this person's palms nearly show the "X" of a treasure map (about 6 or so!) This might not seem like such a big deal compared to others mentioned on this list, but this is a remarkable enigma as far as we are concerned.

Rare Thumb Positions 

Without thinking about the movements of your hands, clasp your fingers together comfortably. Now, look down at your thumbs and notice which is on top. Or, if your thumbs are parallel to each other, you are a lucky member of a very small percentage of humans!

Clasped hands, Thumb, Mutation
Kevin Nixon/Future/Shutterstock

According to NORD, if you crossed left thumb over right or vice versa, your brain is dominated by either the left or right hemisphere. However, if you clasped your hands and both thumbs ended up parallel to each other, pat yourself on the back because that is considered very unique!


If there is any confusion about what this next condition truly means, allow us to help you out here. According to HealthPlus, "gleeking" - or to "gleek" - is the ability to squirt saliva from the glands under one's tongue. Intrigued yet? Wait, we should warn you...

genetic mutation
ClocXa via Facebook

This may occasionally (and awkwardly) happen by accident while in conversation or even yawning. However, it is actually just a natural occurrence that shouldn't cause any alarm or discomfort. Additionally, some people with the unique condition can even do it on command!


This girl is named Lilly, and unfortunately, due to the beautifully unique hair trait that she has had since birth, she's grown accustomed to lots of stares. Since then, she has learned to stand up for herself and accept her hair for what NORD suggested it is: Piebaldism.

Piebald, Genetic condition, Hair
Instagram via @lillyrosemccombie

Over the years, Lilly has grown to love her uniquely white hair. According to NORD, this drastic difference in hair color can be caused by a lack of pigment, or premature graying, in the hair above Lilly's forehead. Today, the young girl is a thriving model on-the-rise, and we can certainly see why!

Complete Heterochromia 

Meet Mekhi Alante Lucky. He is a model, and much like actress Kate Bosworth, he has different colored eyes. However, Lucky is a prime example of what the American Academy of Ophthalmology (AAO) refers to as Complete Heterochromia. This is when a person's eyes are two completely different colors. 

Heterochromia Mekhi Alante Lucky
Instagram via @officialmekhilucky_

Here, it is clear that one of Mekhi's irises is ocean blue, while the other is chocolate brown. The young model has shared on his social media that "People stare at [him] all the time." But, with eyes like his, can we blame them? This is what people buy colored contacts to achieve!


Elisany da Cruz Silva is a model with Gigantism. According to her story on Healthline, Silva grew to the height of 6 foot 9 inches due to a tumor on her pituitary gland. This massive growth spurt occurred because Elisany's body produced too much somatotropin, or the growth hormone, as explained by the medical platform.

Elisane, Tallest woman, Medical
Instagram via @elisane_oficial

The tall woman eventually met a man and fell in love like many other people, and he happened to be of average height! Silva's story, along with the many others on this list, proves that unique traits can set humans apart in some of the best ways imaginable.